This item contains entries about prominent people (primarily accounts of their deaths); Philadelphia events and gossip; the Pennsylvania Hospital; questions for Meriwether Lewis on Indian physical history, medicine, morals, and religion; and his views on marriage, religion, physicians, etc. Also includes meeting with Captain Wells and Little Turtle; speculations on Indian skin color at the equator.

The collection includes letters between Hutchinson and his uncle Israel Pemberton, written while Hutchinson was a student of medicine in London. There are also 12 tickets of admission to medical lectures in Philadelphia and London, including one given by William Hunter, and 3 unused cards of admission to Hutchinson's own lectures. Miscellaneous items include Hutchinson's marriage certificate; genealogical data on the Hutchinson, Hare, and Pemberton families; and stock certificates, 1857-1872, of the McKean and Elk Land and Improvement Company. Materials dated post-1793 are to and from Hutchinson family members.